Closed system use of isoflurane and enflurane

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The invention and development of enflurane, isoflurane, sevoflurane, and desflurane.

Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens other than F or 2 or more H with at least one Br or Cl were the best anesthetics.

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The effect of halothane, enflurane and isoflurane on the circulation.

This study, in open-chested dogs, sought to explore the relationship between whole-body oxygen delivery and oxygen consumption during anaesthesia, using increasing concentrations of halothane, enflurane and isoflurane. Results indicate that the cardiac index and oxygen delivery became critical at less than 1 MAC (minimal alveolar concentration of anaesthetic) for the three commonly used vapours...

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Effects of halothane, isoflurane and enflurane on ventilation in children.

The ventilatory effects of halothane in eight children were compared with those of isoflurane in eight children and enflurane in six children. All studies were completed before surgery commenced, and the children received no preoperative medication. The depression of ventilation produced by the three agents increased in a dose-related fashion as the alveolar concentrations were increased, and t...

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Interactions between nicardipine and enflurane, isoflurane, and sevoflurane.

PURPOSE During nicardipine induced hypotension, different inhalational anaesthetics may have different effects on haemodynamic variables, sympathetic function and drug metabolism. Therefore, the haemodynamic effects and pharmacokinetics of nicardipine were studied in the presence of the three inhalation anaesthetics enflurane, isoflurane and sevoflurane. METHODS Thirty patients scheduled for ...

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Sevoflurane, enflurane and isoflurane have no persistent postanaesthetic effects on the central nervous system in cats.

Several reports have appeared on postanaesthetic convulsive disorders in humans after enflurane and isoflurane anaesthesia. However, it is controversial if enflurane induces epileptiform electroencephalogram (EEG), abnormal behaviour, or both, lasting for several days after anaesthesia in laboratory animals. We chronically implanted electrodes for EEG recording in the cortex, medial amygdala an...

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ژورنال

عنوان ژورنال: Anaesthesia

سال: 1990

ISSN: 0003-2409,1365-2044

DOI: 10.1111/j.1365-2044.1990.tb14368.x